BIX 01294
- Product Name
- BIX 01294
- CAS No.
- 1392399-03-9
- Chemical Name
- BIX 01294
- Synonyms
- CS-1418;BIX 01204;BIX01294 HCl;BIX01294 triHCl;BIX 01294 USP/EP/BP;BIX01294 hydrochloride;BIX01294 3hydrochloride;Trihydrochloride Hydrate;BIX 01294 Trihydrochloride Hydrate;BIX01294 hydrochloride BIX-01294 HCL
- CBNumber
- CB92677401
- Molecular Formula
- C28H41Cl3N6O2
- Formula Weight
- 600.02314
- MOL File
- 1392399-03-9.mol
BIX 01294 Property
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- H2O: >20mg/mL
- form
- powder
- color
- white
Safety
- WGK Germany
- 3
- HS Code
- 2933.99.8290
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B9311
- Product name
- BIX 01294 trihydrochloride hydrate
- Purity
- ≥98% (HPLC), powder
- Packaging
- 5mg
- Price
- $221
- Updated
- 2024/03/01
- Product number
- B9311
- Product name
- BIX 01294 trihydrochloride hydrate
- Purity
- ≥98% (HPLC), powder
- Packaging
- 25mg
- Price
- $525
- Updated
- 2024/03/01
- Product number
- B4211
- Product name
- BIX 01294 Trihydrochloride Hydrate
- Purity
- >85.0%(N)
- Packaging
- 25mg
- Price
- $608
- Updated
- 2024/03/01
- Product number
- B591600
- Product name
- BIX01294Trihydrochloride
- Packaging
- 250mg
- Price
- $1175
- Updated
- 2021/12/16
- Product number
- BB162787
- Product name
- BIX 01294
- Packaging
- 50mg
- Price
- $437.5
- Updated
- 2021/12/16
BIX 01294 Chemical Properties,Usage,Production
Uses
BIX 01294 trihydrochloride hydrate has been used:
- as a histone methylation inhibitor to treat E4 cells for analysing green fluorescent protein (d2EGFP) expression
- to investigate the role of G9a in neuroblastoma tumor growth
- as specific inhibitor of G9a to treat the SK-N-AS, BE(2)-C, SK-N-DZ, SK-N-F1, and SHEP1 neuroblastoma cell lines
General Description
BIX-01294, a diazepin-quinazolinamine derivative, is a histone-lysine methyltransferase (HMTase) inhibitor that modulates the epigenetic status of chromatin. BIX-01294 inhibits the G9aHMTase dependent levels of histone-3 lysine (9) methylation (H3K9me). Bix-01294 and valproic acid, a histone deacetylase (HDAC) inhibitor, may replace the requirement for ectopic OCT4 (POU5F1) and cMyc respectively in pluripotent stem cell induction (iPS) recipes.
Biochem/physiol Actions
BIX 01294 is a selective histone methyl transferase inhibitor. In its inhibition of the histone lysine methyltransferases, BIX 01294 does not compete with cofactor S-adenosyl-methionine. The target enzyme is G9a, and it selectively impairs G9a HMTase and the generation of H3K9me2 in vitro.
storage
room temperature (desiccate)